Follicular Epithelial Cell Hypertrophy Induced by Chronic Oral
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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) affects the thyroid morphologically and/or functionally in adult animals. Recently, the National Toxicology Program conducted a 2-year gavage study of TCDD in female Harlan Sprague–Dawley rats. The only treatment-related alterations found in thyroid follicles were decreased luminal size and increased height of the follicular epithelial cells, without prominent protrusion into the lumen.
A) Follicular hypertrophy in the thyroid in a female rat exposed to a
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Thyroid gland. Hyperplasia of the follicle-lining epithelial cells.