Slow, tight-binding inhibition of PDF by actinonin induces

Modification of the backbone of PDFIs to improve PDFI potency in vitro.

PDF] Avibactam is a covalent, reversible, non–β-lactam β-lactamase inhibitor

Thierry MEINNEL, Director, PhD, French National Centre for Scientific Research, Paris, CNRS, Institute for Integrative Biology of the Cell

Carmela GIGLIONE, Laboratory Head, PhD, Université Paris-Saclay, Paris

PDF) Ion mobility coupled to native mass spectrometry as a relevant tool to investigate extremely small ligand-induced conformational changes

Reaction catalysed by FAH and TS mimic inhibitors The tetrahedral

PDF) Trapping Conformational States Along Ligand-Binding Dynamics of Peptide Deformylase: The Impact of Induced Fit on Enzyme Catalysis

Ion mobility coupled to native mass spectrometry as a relevant tool to investigate extremely small ligand-induced conformational changes - Analyst (RSC Publishing) DOI:10.1039/C5AN01311A

7: Tight Binding Inhibition

Michel Desmadril's research works Université Paris-Saclay, Paris and other places

Frédéric Dardel's research works Paris Descartes University, Paris and other places

Aminopeptidase inhibitors bestatin and actinonin inhibit cell proliferation of myeloma cells predominantly by intracellular interactions - ScienceDirect

Peptide Deformylase as an Antibacterial Drug Target: Target Validation and Resistance Development

Isabelle ARTAUD, Research Director, PhD, French National Centre for Scientific Research, Paris, CNRS, Chemistry and Biology Interdisciplinar Centre paris Descartes University france