Inflammatory myofibroblastic tumour of an unusual presentation in the uterine cervix: a case report, World Journal of Surgical Oncology

Background Inflammatory myofibroblastic tumour is an infrequent mesenchymal neoplasia of unknown aetiology and variable behaviour, ranging from rather benign lesions to locally aggressive and even metastatic disease. Its presence has been described in almost all organs; however, its location in the female genital tract has rarely been reported. Case presentation We present the case of a 47-year-old female, who was studied in our institution for a recent medical history of several weeks of dyspareunia and abdominal pain. She underwent pertinent studies including ultrasonography and CT scan. Under suspicion of degenerated leiomyoma, a total hysterectomy was performed. Unexpectedly, the pathological study of the surgical specimen showed very few tumour cells with focal fusiform morphology surrounded by an abundant inflammatory infiltrate; a thorough immunohistochemistry study lead to myofibroblastic tumour of the cervix diagnosis. A PET-CT scan did not show metastatic disease. The patient did not undergo any adjuvant treatment, and she is currently on surveillance with no evidence of disease relapse. Conclusions Inflammatory myofibroblastic tumour remains a rare entity yet to be fully elucidated. The diagnosis is based on pathological study due to the lack of typical clinical manifestations and typical radiological images. Surgical resection is the most frequent treatment, whereas chemotherapy and radiotherapy are restricted to locally advanced or metastatic disease. Tirosine kinase inhibitor crizotinib has shown promising results especially in tumours harbouring ALK mutation.

Inflammatory Myofibroblastic Tumor of the Subglottis: A Rare Case Report - Zhe Chen, Wei Xiao, Tao Peng, Linfeng Ye, 2022

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Inflammatory Myofibroblastic Tumor of the Uterus: An Under-recognized Entity—A Case Report and Literature Review

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Journal of Clinical Images and Medical Case Reports

Anaplastic lymphoma kinase-positive inflammatory myofibroblastic tumor of the breast: a case report and review of the literature, Surgical Case Reports

Inflammatory myofibroblastic tumour of an unusual presentation in the uterine cervix: a case report, World Journal of Surgical Oncology

Transvaginal Myomectomy for A Huge Cervical Myoma with Cervical Cyst: A Case Report and Review of the Literature

Identification of CARS-ALK Fusion in Primary and Metastatic Lesions of an Inflammatory Myofibroblastic Tumor

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